Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 2/20 | 0.55 |
| ▸ | CASP7 | P55210 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28034968 | 0.86 | CFTR (0.59) | ALDH1A1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL16649554 | 0.81 | KMT2A (0.68) | ALDH1A1LMNAMAPTKMT2ANPSR1 | |
| SCHEMBL2641012 | 0.76 | CFTR (0.56) | — | |
| SCHEMBL979684 | 0.75 | KDM4E (0.69) | MAPK1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL8891951 | 0.75 | MAPT (0.44) | MAPK1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL5166280 | 0.74 | TP53 (0.45) | MAPK1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL981293 | 0.74 | KDM4E (0.67) | MAPK1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL981898 | 0.74 | KDM4E (1.00) | MAPK1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL5545639 | 0.74 | KDM4E (0.67) | MAPK1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL31315695 | 0.73 | ALDH1A1 (0.51) | MAPK1KDM4EALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |