Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 8/20 | 0.46 |
| ▸ | SGMS1 | Q86VZ5 | 4/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163615 | 0.87 | HDAC4 (0.58) | HDAC4MEN1PGRKMT2ASRC | |
| SCHEMBL5164782 | 0.87 | HDAC4 (0.58) | HDAC4MEN1PGRKMT2ASRC | |
| SCHEMBL5166077 | 0.85 | HDAC4 (0.56) | HDAC4MEN1PGRKMT2ASRC | |
| SCHEMBL14376051 | 0.77 | HDAC4 (0.78) | HDAC4MEN1PGRKMT2ASRC | |
| SCHEMBL10671529 | 0.77 | MEN1 (0.81) | HDAC4MEN1PGRKMT2ASRC | |
| SCHEMBL10670928 | 0.76 | MEN1 (0.61) | HDAC4MEN1PGRKMT2ASRC | |
| SCHEMBL7558383 | 0.75 | HDAC4 (0.71) | HDAC4MEN1PGRKMT2ASRC | |
| SCHEMBL10668823 | 0.74 | KMT2A (0.81) | HDAC4MEN1PGRKMT2ASRC | |
| SCHEMBL24864729 | 0.74 | ALDH1A1 (0.60) | MEN1PGRKMT2AALDH1A1MAPT | |
| SCHEMBL10676764 | 0.74 | MEN1 (0.85) | HDAC4MEN1PGRKMT2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224172-B1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2007-04-04 | — | — | EP | disclosed |
| US-6395750-B1 | Includes laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide and its salts; breat or prostate cancer | ACTIVE BIOTECH AB (SE) | 2002-05-28 | — | — | US | disclosed |