Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 4/20 | 0.38 |
| ▸ | ARG1 | P05089 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823349 | 1.00 | KMT2A (0.48) | KMT2ABLMALOX15PMP22CHRM2 | |
| SCHEMBL9823333 | 0.98 | BLM (0.50) | KMT2ABLMALOX15PMP22CHRM2 | |
| SCHEMBL8209380 | 0.93 | KMT2A (0.54) | KMT2ABLMALOX15PMP22CHRM2 | |
| SCHEMBL28468181 | 0.86 | ALDH1A1 (0.55) | KMT2AALOX15PMP22GSRALDH1A1 | |
| SCHEMBL556329 | 0.85 | PAOX (0.50) | KMT2ABLMCHRM2CHRM4CHRM1 | |
| SCHEMBL15618145 | 0.84 | BLM (0.71) | KMT2ABLMALOX15PMP22GSR | |
| SCHEMBL1332756 | 0.82 | ALOX15 (0.68) | KMT2ABLMALOX15PMP22GSR | |
| SCHEMBL1262932 | 0.82 | ALOX15 (0.68) | KMT2ABLMALOX15PMP22GSR | |
| SCHEMBL240508 | 0.82 | ALOX15 (0.68) | KMT2ABLMALOX15PMP22GSR | |
| SCHEMBL240509 | 0.82 | ALOX15 (0.68) | KMT2ABLMALOX15PMP22GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768956-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006005955-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-01-19 | — | — | WO | disclosed |