Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13376041 | 0.79 | SMN1; SMN2 (0.51) | KDM4EALDH1A1HSD17B10SMN1; SMN2EP300 | |
| SCHEMBL1882967 | 0.79 | SMN1; SMN2 (0.47) | KDM4EALDH1A1HSD17B10SMN1; SMN2EP300 | |
| SCHEMBL30719979 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10SMN1; SMN2CYP1A2 | |
| SCHEMBL29157893 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10SMN1; SMN2CYP1A2 | |
| SCHEMBL1885107 | 0.77 | SMN1; SMN2 (0.45) | KDM4ESMN1; SMN2CYP1A2BLMEP300 | |
| SCHEMBL10079684 | 0.76 | PDCD1 (0.48) | KDM4ESMN1; SMN2EP300KAT2BCD274 | |
| SCHEMBL10059404 | 0.76 | SMN1; SMN2 (0.44) | KDM4EALDH1A1HSD17B10SMN1; SMN2EP300 | |
| SCHEMBL30052176 | 0.74 | EP300 (0.50) | KDM4EALDH1A1HSD17B10SMN1; SMN2EP300 | |
| SCHEMBL1885114 | 0.74 | EP300 (0.50) | KDM4EALDH1A1HSD17B10SMN1; SMN2EP300 | |
| SCHEMBL10025187 | 0.74 | KDM4E (0.74) | KDM4EALDH1A1HSD17B10SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0866656-B1 | USE OF N-SUBSTITUTED PYRIDONES AS TUMOR NECROSIS FACTOR ALPHA INHIBITORS | MARGOLIN SOLOMON B (US) | 2007-04-25 | — | — | EP | claimed |
| EP-1261338-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR INC (US) | 2006-06-14 | — | — | EP | claimed |
| EP-1069898-B1 | TOPICAL ANTISEPTIC COMPOSITIONS AND METHODS | MARGOLIN SOLOMON B (US) | 2004-05-12 | — | — | EP | claimed |
| EP-0813409-B1 | TREATMENT OF CYTOKINE GROWTH FACTOR CAUSED DISORDERS | MARGOLIN SOLOMON B (US) | 2004-05-06 | — | — | EP | claimed |
| US-5962478-A | ADMINISTERING A N-SUBSTITUTED 2(1H)PYRIDONE | INTERMUNE, INC. | 1999-10-05 | — | — | US | claimed |
| US-12023342-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | AVALYN PHARMA INC. (US) | 2024-07-02 | — | — | US | disclosed |
| CN-117651698-A | Pyridone MK2 inhibitors and uses thereof | 新特拉有限公司 | 2024-03-05 | — | — | CN | disclosed |
| US-20230330357-A1 | NEBULIZER DEVICE OPTIMIZATION FOR IMPROVED AEROSOL PARAMETERS AND USES THEREOF | AVALYN PHARMA INC. | 2023-10-19 | — | — | US | disclosed |
| EP-4217026-A1 | NEBULIZER DEVICE OPTIMIZATION FOR IMPROVED AEROSOL PARAMETERS AND USES THEREOF | Avalyn Pharma Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20230201487-A1 | NEBULIZER DEVICE OPTIMIZATION FOR IMPROVED AEROSOL PARAMETERS AND USES THEREOF | AVALYN PHARMA INC. | 2023-06-29 | — | — | US | disclosed |
| US-20230149375-A1 | AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF | AVALYN PHARMA INC. | 2023-05-18 | — | — | US | disclosed |
| US-11559520-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | AVALYN PHARMA INC. (US) | 2023-01-24 | — | — | US | disclosed |
| EP-1261338-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR INC (US) | 2006-06-14 | — | — | EP | disclosed |
| US-6956044-B1 | Compositions and methods for treatment of epilepsy | INTERMUNE, INC. | 2005-10-18 | — | — | US | disclosed |
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| US-5962478-A | ADMINISTERING A N-SUBSTITUTED 2(1H)PYRIDONE | INTERMUNE, INC. | 1999-10-05 | — | — | US | disclosed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |
| US-4052509-A | 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1977-10-04 | — | — | US | disclosed |
| US-4042699-A | 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1977-08-16 | — | — | US | disclosed |
| US-3974281-A | ANALGESICS, ANTI-PYRETIC AND ANTI-INFLAMMATORY AGENTS | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1976-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230149375-A1 | AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF | PLPBP, PIR, PDXK | KDM4E 2879/4885ALDH1A1 167/4885HSD17B10 2978/4885 |
| US-11559520-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | PLPBP, PIR, PDXK | KDM4E 2879/4885ALDH1A1 167/4885HSD17B10 2978/4885 |
| US-12023342-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | PLPBP, PIR, PDXK | KDM4E 2879/4885ALDH1A1 167/4885HSD17B10 2978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.