Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167941 | 0.90 | PKM (0.39) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5164945 | 0.88 | GAA (0.35) | ALDH1A1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL5166481 | 0.86 | RPS6KB2 (0.38) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5164992 | 0.77 | GAA (0.33) | SMN1; SMN2ALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL5167506 | 0.76 | KLK7 (0.40) | ALDH1A1PKMKDM4EHPGDHSD17B10 | |
| SCHEMBL6750698 | 0.75 | RPS6KB2 (0.42) | SMN1; SMN2ALDH1A1PKMKMT2ATOP2A | |
| SCHEMBL5165554 | 0.74 | GAA (0.46) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5165905 | 0.74 | PKM (0.38) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1PKM | |
| SCHEMBL5164942 | 0.73 | MKNK1 (0.36) | CYP2C9CYP2C19ALDH1A1KMT2AKDM4E | |
| SCHEMBL5165500 | 0.73 | KMT2A (0.37) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326613-B2 | USE OF SUBSTITUTED IMIDAZO 1,2-A|PYRIDINE-, IMIDAZO ¬1,2-A|PYRIMIDINE AND IMIDAZO ¬1,2-A|PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2007-04-18 | — | — | EP | disclosed |
| EP-1326613-B1 | USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO [1,2-A]PYRIMIDINE AND IMIDAZO [1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2004-06-02 | — | — | EP | disclosed |