Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 17/20 | 0.55 |
| ▸ | GUCY1B1 | Q02153 | 17/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.53 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516565 | 0.87 | GUCY1A1 (0.47) | GUCY1A1GUCY1B1KCNH2RORCRARG | |
| SCHEMBL516992 | 0.83 | GUCY1A1 (0.42) | GUCY1A1GUCY1B1KCNH2RORC | |
| SCHEMBL15385073 | 0.82 | ALDH1A1 (0.43) | GUCY1A1GUCY1B1KCNH2RORC | |
| SCHEMBL10188875 | 0.80 | GUCY1A1 (0.41) | GUCY1A1GUCY1B1KCNH2RORC | |
| SCHEMBL10151844 | 0.80 | GUCY1A1 (0.51) | GUCY1A1GUCY1B1KCNH2RORC | |
| SCHEMBL516306 | 0.79 | GUCY1A1 (0.52) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL516245 | 0.78 | MAPT (0.53) | GUCY1A1GUCY1B1KCNH2RORC | |
| SCHEMBL10151845 | 0.77 | GUCY1A1 (0.42) | GUCY1A1GUCY1B1KCNH2RORC | |
| Formic Acid SCHEMBL516290 | 0.76 | GUCY1A1 (0.51) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2447914 | 0.76 | GUCY1A1 (0.82) | GUCY1A1GUCY1B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303559-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | BAYER IP GMBH (DE) | 2013-11-14 | — | — | US | disclosed |
| US-20120029002-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029002-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | PKM, BRD3, TNNI3 | GUCY1A1 3203/4885GUCY1B1 2537/4885KCNH2 302/4885 |
| US-20130303559-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | PKM, BRD3, TNNI3 | GUCY1A1 3203/4885GUCY1B1 2537/4885KCNH2 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.