SCHEMBL5167565

SCHEMBL5167565

Cc1ccc2oc3cc(CN4CCOCC4)ccc3c(=S)c2c1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.54
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
ATM Q13315 1/20 0.47
PRKDC P78527 1/20 0.43
HRH3 Q9Y5N1 1/20 0.41
KMT2A Q03164 2/20 0.41
NR2E3 Q9Y5X4 1/20 0.41
DRD2 P14416 2/20 0.41
DRD4 P21917 2/20 0.41
HTT P42858 1/20 0.41
MEN1 O00255 1/20 0.41
KDM4E B2RXH2 2/20 0.40
HTR1A P08908 3/20 0.40
HTR7 P34969 3/20 0.40
HTR6 P50406 3/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
PARP1 P09874 1/20 0.40
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5168930 0.83 NPC1 (0.57) HSD17B10NPC1RAB9AATMHRH3
SCHEMBL26766706 0.75 HSD17B10 (0.52) HSD17B10NPC1RAB9AATMKMT2A
SCHEMBL11864 0.71 HRH3 (0.71) HRH3KMT2AMEN1SMN1; SMN2POLB
SCHEMBL14791028 0.70 HRH3 (0.69) HRH3KMT2AMEN1SMN1; SMN2POLB
SCHEMBL14787825 0.70 HRH3 (0.69) HRH3KMT2AMEN1SMN1; SMN2POLB
SCHEMBL11158833 0.69 MAOB (0.54) HSD17B10NPC1KMT2AHTTMEN1
SCHEMBL29501109 0.69 HSD17B10 (0.48) HSD17B10NPC1RAB9AATMHRH3
SCHEMBL52197 0.69 HSD17B10 (0.48) HSD17B10NPC1RAB9AATMHRH3
SCHEMBL178443 0.69 NCF1 (0.66) HRH3HTTKDM4ESMN1; SMN2
SCHEMBL1258329 0.68 MAOB (0.50) HSD17B10NPC1RAB9AKMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1558402-B1 METHOD FOR PRODUCING UV ABSORPTION LAYERS ON SUBSTRATES CIBA SC HOLDING AG (CH) 2007-04-18 EP disclosed
EP-1558402-A2 METHOD FOR PRODUCING UV ABSORPTION LAYERS ON SUBSTRATES Ciba Specialty Chemicals Holding Inc. (CH) 2005-08-03 EP disclosed
WO-2004035667-A2 METHOD FOR PRODUCING UV ABSORPTION LAYERS ON SUBSTRATES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-04-29 WO disclosed
EP-1135219-B1 METHOD FOR PRODUCING ADHESIVE SURFACE COATINGS CIBA SC HOLDING AG (CH) 2004-01-28 EP disclosed
EP-1135219-A1 METHOD FOR PRODUCING ADHESIVE SURFACE COATINGS Ciba SC Holding AG (CH) 2001-09-26 EP disclosed
WO-2000024527-A1 METHOD FOR PRODUCING ADHESIVE SURFACE COATINGS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-05-04 WO disclosed
EP-0425440-B1 Method of adjusting the photosensitivity of photopolymerizable compositions CIBA GEIGY AG (CH) 1994-11-17 EP disclosed
EP-0287516-B1 PHOTOPOLYMERIZABLE ADHESIVES CIBA-GEIGY AG (CH) 1993-03-31 EP disclosed
EP-0425440-A1 Method of adjusting the photosensitivity of photopolymerizable compositions CIBA-GEIGY AG (CH) 1991-05-02 EP disclosed
EP-0287516-A2 Photopolymerizable adhesives CIBA-GEIGY AG (CH) 1988-10-19 EP disclosed