Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516773 | 1.00 | PLAU (0.42) | PLAUKDM4EMEN1KMT2AHTT | |
| SCHEMBL1036680 | 0.87 | KDM4E (0.44) | KDM4EMEN1KMT2AHTTHSP90AA1 | |
| SCHEMBL1036682 | 0.87 | KDM4E (0.44) | KDM4EMEN1KMT2AHTTHSP90AA1 | |
| SCHEMBL21625618 | 0.82 | KDM4E (0.51) | KDM4EMEN1KMT2AHTTHSP90AA1 | |
| SCHEMBL21625619 | 0.82 | KDM4E (0.51) | KDM4EMEN1KMT2AHTTHSP90AA1 | |
| SCHEMBL31684422 | 0.82 | KDM4E (0.51) | KDM4EMEN1KMT2AHTTHSP90AA1 | |
| SCHEMBL516559 | 0.78 | CCR1 (0.63) | PLAUKDM4EMEN1KMT2AHTT | |
| SCHEMBL16643739 | 0.74 | KMT2A (0.50) | KDM4EMEN1KMT2AHTTHSP90AA1 | |
| SCHEMBL18980187 | 0.74 | KMT2A (0.50) | KDM4EMEN1KMT2AHTTHSP90AA1 | |
| SCHEMBL7749251 | 0.73 | CCR1 (0.53) | KDM4EMEN1KMT2AHTTHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414353-A1 | ISOXAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2012-02-08 | — | — | EP | disclosed |
| US-20120030841-A1 | Isoxazoline compounds for combating invertebrate pests | BASF SE (DE) | 2012-02-02 | — | — | US | disclosed |
| WO-2010112545-A1 | ISOXAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120030841-A1 | Isoxazoline compounds for combating invertebrate pests | PRDX5, PRDX1, PRDX2 | PLAU 4668/4885KDM4E 1400/4885MEN1 4628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.