SCHEMBL516559

SCHEMBL516559

O=Cc1ccnc2c(Br)cccc12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.63
CCR5 P51681 1/20 0.63
CCR8 P51685 1/20 0.63
KMT2A Q03164 5/20 0.51
KDM4E B2RXH2 5/20 0.51
MEN1 O00255 4/20 0.51
HSP90AA1 P07900 2/20 0.51
RAB9A P51151 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
NPC1 O15118 1/20 0.51
IDO1 P14902 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
TRIM24 O15164 1/20 0.43
TRIM33 Q9UPN9 1/20 0.43
PIM1 P11309 2/20 0.39
PIM3 Q86V86 2/20 0.39
HTT P42858 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
USP2 O75604 1/20 0.39
TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1038604 0.86 KDM4E (0.65) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL31553579 0.80 CCR1 (0.71) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL3912822 0.79 CCR1 (0.63) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL21625616 0.79 KDM4E (0.75) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL3829932 0.79 CCR1 (0.63) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL23760627 0.79 CCR1 (0.63) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL1088410 0.78 CCR1 (1.00) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL516773 0.78 PLAU (0.42) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL516772 0.78 PLAU (0.42) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL1335770 0.75 CCR1 (0.58) CCR1CCR5CCR8KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119968452-A Perfume mixture (VI) 西姆莱斯股份公司 2025-05-09 CN claimed
CN-119790128-A Perfume mixture (III) 西姆莱斯股份公司 2025-04-08 CN claimed
CN-119317695-A Perfume mixture (V) 西姆莱斯股份公司 2025-01-14 CN claimed
CN-119317696-A Perfume mixture (V) 西姆莱斯股份公司 2025-01-14 CN claimed
CN-118829416-A Composition (III) 西姆莱斯股份公司 2024-10-22 CN claimed
CN-117813077-A Composition and method for producing the same 西姆莱斯股份公司 2024-04-02 CN claimed
EP-3947351-A2 SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF Board of Regents, The University of Texas System (US) 2022-02-09 EP claimed
CN-103467374-A Synthesis method of 8-bromine-4-carboxyl quinoline CHEMFUTURE PHARMATECH JIANGSU CO LTD 2013-12-25 CN claimed
EP-4665712-A1 COMPOUNDS, THEIR COMPOSITION AND THEIR USE AS NEMATICIDES Bhukhanwala, Komal (IN) 2025-12-24 EP disclosed
WO-2025215062-A1 LIQUID FRAGRANCE COMPLEX FOR LAUNDRY, FRAGRANCE COMPOSITION, AND ASSOCIATED MANUFACTURING METHOD EXPRESSIONS PARFUMEES (FR) 2025-10-16 WO disclosed
US-12358887-B2 IKAROS Zinc Finger Family degraders and uses thereof GILEAD SCIENCES, INC. (US) 2025-07-15 US disclosed
WO-2025106482-A1 COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) 2025-05-22 WO disclosed
CN-119968452-A Perfume mixture (VI) 西姆莱斯股份公司 2025-05-09 CN disclosed
CN-119790128-A Perfume mixture (III) 西姆莱斯股份公司 2025-04-08 CN disclosed
US-20130281431-A1 DNA-PK INHIBITORS VERTEX PHARMACEUTICALS INCORPORATED 2013-10-24 US disclosed
US-20130281431-A1 DNA-PK INHIBITORS VERTEX PHARMACEUTICALS INCORPORATED 2013-10-24 US disclosed
CN-102369199-A Isoxazoline compounds for controlling invertebrate pests BASF SE 2012-03-07 CN disclosed
EP-2414353-A1 ISOXAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2012-02-08 EP disclosed
US-20120030841-A1 Isoxazoline compounds for combating invertebrate pests BASF SE (DE) 2012-02-02 US disclosed
WO-2010112545-A1 ISOXAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2010-10-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12358887-B2 IKAROS Zinc Finger Family degraders and uses thereof IKZF2, IKZF1, IKZF3 CCR1 3850/4885CCR5 4178/4885CCR8 3523/4885
US-20130281431-A1 DNA-PK INHIBITORS POLK, DTYMK, DCK CCR1 2529/4885CCR5 1532/4885CCR8 2117/4885
US-20120030841-A1 Isoxazoline compounds for combating invertebrate pests PRDX5, PRDX1, PRDX2 CCR1 4384/4885CCR5 3366/4885CCR8 4467/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.