Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HAT1 | O14929 | 4/20 | 0.33 |
| ▸ | EP300 | Q09472 | 4/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4805310 | 0.95 | PTGER4 (0.35) | PTGER4PLA2G4ALTB4RKDM1AGPR139 | |
| SCHEMBL4815141 | 0.89 | PTGER4 (0.34) | PTGER4PLA2G4ALTB4RHAT1EP300 | |
| SCHEMBL4812228 | 0.87 | F7 (0.36) | — | |
| SCHEMBL4805981 | 0.86 | ROCK2 (0.38) | PTGER4PLA2G4ALTB4RKDM1AP2RY14 | |
| SCHEMBL4811266 | 0.82 | PTGER4 (0.36) | PTGER4PLA2G4ALTB4RPTGER3 | |
| SCHEMBL4811462 | 0.82 | F7 (0.36) | — | |
| SCHEMBL4805301 | 0.81 | KDM1A (0.36) | PLA2G4ALTB4RKDM1ANR3C1PGR | |
| SCHEMBL4812944 | 0.81 | PLA2G4A (0.38) | PLA2G4ALTB4RKDM1A | |
| SCHEMBL4815680 | 0.80 | PTPRC (0.37) | PTGER4PLA2G4ALTB4R | |
| SCHEMBL4806248 | 0.78 | F2 (0.45) | PLA2G4ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740538-A4 | BICYCLIC HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-12-19 | — | — | EP | disclosed |
| EP-1740538-A2 | BICYCLIC HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005099709-A2 | BICYCLIC HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-27 | — | — | WO | disclosed |