Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166699 | 0.86 | CFTR (0.52) | CFTRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5167410 | 0.72 | CFTR (0.53) | CFTRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5165199 | 0.72 | CFTR (0.53) | CFTRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL21666169 | 0.72 | CFTR (0.51) | CFTRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5165019 | 0.71 | MAPK1 (0.37) | CFTRKDM4EALDH1A1 | |
| SCHEMBL31356641 | 0.70 | MAP3K5 (0.43) | KDM4EASPH | |
| SCHEMBL27381136 | 0.70 | HCAR1 (0.48) | ALDH1A1AR | |
| SCHEMBL6602353 | 0.69 | NOTUM (0.35) | — | |
| SCHEMBL5166472 | 0.69 | CFTR (0.49) | CFTRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5167408 | 0.68 | CFTR (0.60) | CFTRKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773788-A2 | QUINAZOLINE DERIVATIVES | NOVARTIS-PHARMA GMBH (AT) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010591-A2 | QUINAZOLINE DERIVATIVES | NOVARTIS AG (CH) | 2006-02-02 | — | — | WO | disclosed |