Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 7/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165313 | 0.88 | TLR2 (0.39) | MAPK1L3MBTL1TLR2TLR1MAPT | |
| SCHEMBL5167327 | 0.88 | SMN1; SMN2 (0.37) | MAPK1L3MBTL1TLR2TLR1MAPT | |
| SCHEMBL27688725 | 0.85 | TLR2 (0.40) | MAPK1L3MBTL1TLR2TLR1MAPT | |
| SCHEMBL5167789 | 0.85 | TLR2 (0.37) | MAPK1L3MBTL1TLR2TLR1MAPT | |
| SCHEMBL5166699 | 0.83 | CFTR (0.52) | TLR2TLR1MAPTALDH1A1NOTUM | |
| SCHEMBL5167600 | 0.82 | TLR2 (0.44) | TLR2TLR1MAPTSMN1; SMN2SIRT6 | |
| SCHEMBL5167994 | 0.81 | TLR2 (0.43) | TLR2TLR1MAPTSMN1; SMN2SIRT6 | |
| SCHEMBL2597282 | 0.76 | ALDH1A1 (0.56) | MAPK1L3MBTL1MAPTSMN1; SMN2SIRT6 | |
| SCHEMBL5168841 | 0.76 | SIRT6 (0.47) | MAPTSMN1; SMN2SIRT6ALDH1A1KMT2A | |
| SCHEMBL24525434 | 0.75 | NOTUM (0.50) | MAPK1L3MBTL1MAPTSMN1; SMN2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773788-B1 | Quinazoline derivatives | NOVARTIS AG (CH) | 2012-11-14 | — | — | EP | disclosed |
| US-8299085-B2 | Quinazoline derivatives | NOVARTIS AG (CH) | 2012-10-30 | — | — | US | disclosed |
| US-20070208018-A1 | Quinazoline Derivatives | NOVARTIS AG (CH) | 2007-09-06 | — | — | US | disclosed |
| EP-1773788-A2 | QUINAZOLINE DERIVATIVES | NOVARTIS-PHARMA GMBH (AT) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010591-A2 | QUINAZOLINE DERIVATIVES | NOVARTIS AG (CH) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208018-A1 | Quinazoline Derivatives | CYP3A5, CYP3A7, CYP3A4 | MAPK1 2068/4885L3MBTL1 4860/4885TLR2 3794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.