Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735187 | 0.85 | CCNC (0.63) | HDAC3HDAC1HDAC2HDAC6CCNC | |
| SCHEMBL1735164 | 0.82 | SYK (0.55) | IKBKBCHUKSYK | |
| SCHEMBL13605386 | 0.81 | MCHR1 (0.50) | IKBKBCHUKSYKESR1 | |
| SCHEMBL4873274 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL1734133 | 0.81 | SIGMAR1 (0.50) | IKBKBCHUKSYKKDR | |
| Hydrochloric Acid SCHEMBL3844533 | 0.80 | ALDH1A1 (0.69) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL3643668 | 0.78 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ACSNK2A1GRM5 | |
| SCHEMBL27717813 | 0.78 | HDAC1 (0.63) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL12443599 | 0.77 | CCNC (0.52) | HDAC3HDAC1HDAC2HDAC6CCNC | |
| SCHEMBL13605624 | 0.77 | GRM5 (0.65) | ALDH1A1KDM4EHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-A2 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM, LLC (BM) | 2008-06-11 | — | — | EP | claimed |
| WO-2007038669-A2 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2007-04-05 | — | — | WO | claimed |