Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.31 |
| ▸ | FEN1 | P39748 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | GHSR | Q92847 | 2/20 | 0.30 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5183239 | 0.90 | GRM2 (0.32) | XIAPBIRC2BDKRB1 | |
| SCHEMBL5171051 | 0.86 | HRH3 (0.35) | XIAPBIRC2BDKRB1 | |
| SCHEMBL5173427 | 0.86 | ACKR3 (0.36) | CYP4F2CYP4A11BDKRB1 | |
| SCHEMBL5170762 | 0.85 | SMO (0.33) | XIAPBIRC2CYP4F2CYP4A11MAPK1 | |
| SCHEMBL5183097 | 0.85 | CHEK1 (0.31) | XIAPBIRC2GHSRBDKRB1 | |
| SCHEMBL5170769 | 0.85 | SLC18A2 (0.33) | XIAPBIRC2MAPK1GHSR | |
| SCHEMBL5170240 | 0.84 | HRH3 (0.35) | MAPK1BDKRB1 | |
| SCHEMBL5169161 | 0.83 | PRMT5 (0.36) | — | |
| SCHEMBL5171673 | 0.83 | PANK3 (0.37) | — | |
| SCHEMBL5170212 | 0.81 | BDKRB1 (0.30) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |