Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171051 | 0.92 | HRH3 (0.35) | HRH3PARP1BDKRB1BRD4 | |
| SCHEMBL5183239 | 0.89 | GRM2 (0.32) | BDKRB1 | |
| SCHEMBL5170762 | 0.88 | SMO (0.33) | PARP1BDKRB1MAPK1 | |
| SCHEMBL5170245 | 0.86 | HRH3 (0.35) | HRH3PARP1MAP3K5CHEK1NAMPT | |
| SCHEMBL5183097 | 0.84 | CHEK1 (0.31) | BDKRB1CHEK1NAMPTCSF1R | |
| SCHEMBL5170763 | 0.84 | XIAP (0.32) | BDKRB1MAPK1 | |
| SCHEMBL5169161 | 0.82 | PRMT5 (0.36) | HRH3 | |
| SCHEMBL5173427 | 0.81 | ACKR3 (0.36) | PARP1BDKRB1 | |
| SCHEMBL5171933 | 0.80 | HRH3 (0.41) | HRH3PARP1CSF1RHDAC3HDAC1 | |
| SCHEMBL5170212 | 0.79 | BDKRB1 (0.30) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |