Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170240 | 0.92 | HRH3 (0.35) | HRH3BRD4PARP1BDKRB1 | |
| SCHEMBL5183239 | 0.91 | GRM2 (0.32) | XIAPBIRC2BDKRB1 | |
| SCHEMBL5170762 | 0.90 | SMO (0.33) | PARP1XIAPBIRC2BDKRB1 | |
| SCHEMBL5169161 | 0.88 | PRMT5 (0.36) | HRH3 | |
| SCHEMBL5171933 | 0.87 | HRH3 (0.41) | HRH3HRH1PARP1PARP2 | |
| SCHEMBL5170763 | 0.86 | XIAP (0.32) | XIAPBIRC2BDKRB1 | |
| SCHEMBL5183097 | 0.85 | CHEK1 (0.31) | XIAPBIRC2BDKRB1 | |
| SCHEMBL5171053 | 0.85 | HRH3 (0.35) | HRH3HRH1BRD4PARP1PARP2 | |
| SCHEMBL5173427 | 0.83 | ACKR3 (0.36) | PARP1PARP2BDKRB1 | |
| SCHEMBL5172261 | 0.81 | KLKB1 (0.38) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |