Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.33 |
| ▸ | KDM6B | O15054 | 2/20 | 0.33 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171322 | 0.87 | FNTA (0.34) | CYP11B2CYP11B1FNTAFNTBTLR7 | |
| SCHEMBL5171897 | 0.82 | NOTUM (0.35) | CYP1A2LMNACYP2C19SLC18A2KDM4E | |
| SCHEMBL5184067 | 0.76 | GRIN1 (0.34) | GABRA1SLC18A2TDP1 | |
| SCHEMBL5170176 | 0.76 | SLC18A2 (0.36) | ABCB11SLC18A2KDM4EALDH1A1 | |
| SCHEMBL5170187 | 0.75 | SLC18A2 (0.36) | ABCB11SLC18A2KDM4EALDH1A1 | |
| SCHEMBL5170924 | 0.74 | GRIN1 (0.35) | ABCB11SLC18A2KDM4EALDH1A1 | |
| SCHEMBL5173434 | 0.74 | KDM4C (0.35) | ABCB11KDM4CKDM6BSLC18A2KDM4E | |
| SCHEMBL5662423 | 0.73 | ESR2 (0.43) | CYP11B2CYP11B1LMNAALDH1A1 | |
| SCHEMBL5170766 | 0.72 | SMO (0.34) | ABCB11KDM4CSLC18A2KDM4EALDH1A1 | |
| SCHEMBL5170769 | 0.72 | SLC18A2 (0.33) | ABCB11KDM4CSLC18A2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |