Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.33 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5172025 | 0.88 | HRH3 (0.39) | GRIN1GRIN2BGABRA1GHSRENPP2 | |
| SCHEMBL5184064 | 0.85 | GRIN1 (0.33) | GRIN1GRIN2BGABRA1FFAR1TDP1 | |
| SCHEMBL5171897 | 0.81 | NOTUM (0.35) | SLC18A2GHSRPPARDPPARATDP1 | |
| SCHEMBL5170957 | 0.80 | CHRNB2 (0.38) | SLC18A2GHSR | |
| SCHEMBL5171948 | 0.80 | SLC18A2 (0.33) | GRIN1GRIN2BSLC18A2GHSRS1PR1 | |
| SCHEMBL5194064 | 0.78 | HRH3 (0.40) | — | |
| SCHEMBL5171939 | 0.78 | HRH3 (0.40) | GRIN1GRIN2BGABRA1GHSRS1PR1 | |
| SCHEMBL5170946 | 0.76 | GABRA1 (0.39) | GABRA1SLC18A2TDP1 | |
| SCHEMBL5170176 | 0.76 | SLC18A2 (0.36) | SLC18A2 | |
| SCHEMBL5170924 | 0.75 | GRIN1 (0.35) | GRIN1GRIN2BSLC18A2GHSRFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |