Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.33 |
| ▸ | SNRNP200 | O75643 | 2/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171657 | 0.87 | USP30 (0.36) | SNRNP200USP30RBP4SCD | |
| SCHEMBL5170946 | 0.82 | GABRA1 (0.39) | SLC18A2GRM2KDM4EALDH1A1TDP1 | |
| SCHEMBL5184067 | 0.81 | GRIN1 (0.34) | SLC18A2PPARAPPARDTDP1GHSR | |
| SCHEMBL5170176 | 0.76 | SLC18A2 (0.36) | HPGDSMN1; SMN2SLC18A2KDM4EALDH1A1 | |
| SCHEMBL5170187 | 0.75 | SLC18A2 (0.36) | HPGDSMN1; SMN2SLC18A2KDM4EALDH1A1 | |
| SCHEMBL5170766 | 0.74 | SMO (0.34) | HPGDSMN1; SMN2SLC18A2KDM4EALDH1A1 | |
| SCHEMBL5173084 | 0.73 | ESR2 (0.43) | NOTUMHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5171948 | 0.73 | SLC18A2 (0.33) | HPGDSMN1; SMN2SLC18A2KDM4EALDH1A1 | |
| SCHEMBL5183241 | 0.72 | HRH3 (0.33) | HPGDSLC18A2GRM2KDM4EALDH1A1 | |
| SCHEMBL5170924 | 0.72 | GRIN1 (0.35) | HPGDSMN1; SMN2SLC18A2KDM4EPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |