Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 6/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30892436 | 1.00 | KMT2A (0.52) | KMT2AMEN1VCAM1CA2CA9 | |
| SCHEMBL10452713 | 0.85 | KMT2A (0.66) | KMT2AMEN1CA2F2PRSS1 | |
| Sulfamide SCHEMBL5870774 | 0.85 | TDP1 (0.50) | KMT2AMEN1VCAM1CA2CA9 | |
| SCHEMBL28109687 | 0.85 | VCAM1 (0.54) | KMT2AMEN1VCAM1CA2CA9 | |
| SCHEMBL28835817 | 0.84 | VCAM1 (0.52) | KMT2AMEN1VCAM1CA2CA9 | |
| SCHEMBL974628 | 0.84 | KMT2A (0.53) | KMT2AMEN1CA2F2PRSS1 | |
| SCHEMBL7770296 | 0.82 | CA1 (0.53) | KMT2AMEN1CA2F2PRSS1 | |
| SCHEMBL4158554 | 0.81 | KMT2A (0.70) | KMT2AMEN1CA2CA9F2 | |
| SCHEMBL370668 | 0.81 | KMT2A (0.70) | KMT2AMEN1CA2CA9F2 | |
| SCHEMBL7531976 | 0.80 | KMT2A (0.53) | KMT2AMEN1VCAM1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776414-A | A kind of Bcl-2 protein inhibitor and its preparation method and application | 山东大学 | 2019-05-21 | — | — | CN | claimed |
| CN-106608895-A | BCL-2 selective inhibitor with sugar ring structure and application thereof | 苏州国匡医药科技有限公司 | 2017-05-03 | — | — | CN | claimed |
| US-3935005-A | Composition and method for stripping gold and silver | AMERICAN CHEMICAL & REFINING COMPANY, INCORPORATED (US) | 1976-01-27 | — | — | US | claimed |
| CN-110177788-A | Compound as BCL-2 selectivity inducer of apoptosis | 上海复尚慧创医药研究有限公司 | 2019-08-27 | — | — | CN | disclosed |
| CN-109966294-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109897038-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2019-06-18 | — | — | CN | disclosed |
| CN-109776414-A | A kind of Bcl-2 protein inhibitor and its preparation method and application | 山东大学 | 2019-05-21 | — | — | CN | disclosed |
| CN-109641897-A | Bcl-2 selective depressant and its preparation and use | 北京赛林泰医药技术有限公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-106008466-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-106008322-B | sulfonamide derivatives as BC L-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-108175749-A | The solid dispersions of melt extrusion containing cell death inducer | 艾伯维爱尔兰无限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-1529591-A | Method for synthesizing phenol-containing compounds | ʷ��˿�������ȳ�ķ����˾ | 2004-09-15 | — | — | CN | disclosed |
| CN-1424910-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2003-06-18 | — | — | CN | disclosed |
| CN-1418096-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2003-05-14 | — | — | CN | disclosed |
| EP-0463993-B1 | Process for the preparation of aminoanthraquinone derivatives | CIBA SC HOLDING AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| CN-1334726-A | Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2002-02-06 | — | — | CN | disclosed |
| US-5196553-A | From bromaminic acid and a benzenesulfonamide or an amide, copper/I/ catalyst formed by in situ reduction of a copper/II/ salt, less copper required | CIBA-GEIGY CORPORATION (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0463993-A1 | Process for the preparation of aminoanthraquinone derivatives | CIBA-GEIGY AG (CH) | 1992-01-02 | — | — | EP | disclosed |
| US-3935005-A | Composition and method for stripping gold and silver | AMERICAN CHEMICAL & REFINING COMPANY, INCORPORATED (US) | 1976-01-27 | — | — | US | disclosed |
| US-3935005-A | Composition and method for stripping gold and silver | AMERICAN CHEMICAL & REFINING COMPANY, INCORPORATED (US) | 1976-01-27 | — | — | US | disclosed |