Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171421 | 0.84 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL5171535 | 0.82 | CNR1 (0.45) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL631407 | 0.79 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL8738834 | 0.75 | MAPT (0.58) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL5172899 | 0.75 | ALDH1A1 (0.57) | MAPTSMN1; SMN2ALDH1A1GAANPC1 | |
| SCHEMBL17160801 | 0.74 | ALDH1A1 (0.55) | MAPTALDH1A1KMT2AGAATP53 | |
| SCHEMBL4886100 | 0.74 | ALDH1A1 (0.55) | MAPTALDH1A1KMT2AGAATP53 | |
| SCHEMBL1379670 | 0.71 | MAPT (0.66) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL29522596 | 0.71 | ALDH1A1 (0.60) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL2107534 | 0.70 | HDAC1 (0.76) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | disclosed |