Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197772 | 0.89 | S1PR1 (0.39) | S1PR1S1PR3OPRK1HCRTR1HCRTR2 | |
| SCHEMBL5172129 | 0.87 | ADRB3 (0.31) | CNR2ADRB3SLC6A2SLC6A4HCRTR1 | |
| SCHEMBL5182852 | 0.86 | S1PR1 (0.38) | S1PR1S1PR3HCRTR1HCRTR2 | |
| SCHEMBL5159383 | 0.85 | STAT3 (0.37) | OPRK1OPRM1 | |
| SCHEMBL5170769 | 0.82 | SLC18A2 (0.33) | — | |
| SCHEMBL5183241 | 0.81 | HRH3 (0.33) | — | |
| SCHEMBL5183100 | 0.80 | ACACB (0.32) | — | |
| SCHEMBL5171053 | 0.80 | HRH3 (0.35) | — | |
| SCHEMBL5173434 | 0.79 | KDM4C (0.35) | — | |
| SCHEMBL5170766 | 0.79 | SMO (0.34) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |