Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197766 | 0.89 | S1PR1 (0.36) | ACKR3TBK1 | |
| SCHEMBL5172133 | 0.87 | CNR2 (0.33) | ADRB3SLC6A2SLC6A4HCRTR1HCRTR2 | |
| SCHEMBL5182850 | 0.85 | ACKR3 (0.38) | HCRTR1HCRTR2ACKR3TBK1 | |
| SCHEMBL5159375 | 0.82 | STAT3 (0.38) | — | |
| SCHEMBL5170763 | 0.81 | XIAP (0.32) | — | |
| SCHEMBL5183239 | 0.81 | GRM2 (0.32) | — | |
| SCHEMBL5183097 | 0.80 | CHEK1 (0.31) | — | |
| SCHEMBL5171051 | 0.79 | HRH3 (0.35) | — | |
| SCHEMBL5664943 | 0.79 | GPR119 (0.42) | TBK1 | |
| SCHEMBL5173427 | 0.79 | ACKR3 (0.36) | ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |