Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.30 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170245 | 0.92 | HRH3 (0.35) | HRH3NAMPTBRD4PARP1KDM4C | |
| SCHEMBL5183241 | 0.91 | HRH3 (0.33) | HRH3XIAPBIRC2KDM4C | |
| SCHEMBL5170766 | 0.90 | SMO (0.34) | HRH3KDM4C | |
| SCHEMBL5171939 | 0.88 | HRH3 (0.40) | HRH3HRH1 | |
| SCHEMBL5169168 | 0.88 | PRMT5 (0.37) | HRH3CXCR3NAMPT | |
| SCHEMBL5170769 | 0.87 | SLC18A2 (0.33) | XIAPBIRC2KDM4C | |
| SCHEMBL5183100 | 0.85 | ACACB (0.32) | NAMPTXIAPBIRC2SCD | |
| SCHEMBL5171051 | 0.85 | HRH3 (0.35) | HRH3HRH1BRD4PARP1PARP2 | |
| SCHEMBL5173434 | 0.84 | KDM4C (0.35) | PARP1PARP2KDM4C | |
| SCHEMBL5171657 | 0.83 | USP30 (0.36) | BRD4SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |