Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175410 | 1.00 | CHRNB2 (0.45) | CHRNB2CHRNA4 | |
| SCHEMBL5173829 | 0.83 | MMP2 (0.39) | — | |
| SCHEMBL5172803 | 0.80 | CHRNB2 (0.46) | CHRNB2CHRNA4 | |
| SCHEMBL5173626 | 0.79 | CHRNB2 (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL5173631 | 0.79 | CHRNB2 (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL5172747 | 0.79 | CHRNB2 (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL5174095 | 0.77 | CHRNB2 (0.42) | CHRNB2CHRNA4 | |
| SCHEMBL5174090 | 0.77 | CHRNB2 (0.42) | CHRNB2CHRNA4 | |
| SCHEMBL7228431 | 0.77 | CHRNB2 (0.42) | CHRNB2CHRNA4 | |
| SCHEMBL2889610 | 0.73 | CHRNB2 (0.42) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257535-B1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2007-05-23 | — | — | EP | disclosed |
| US-6656958-B2 | Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers; selectively controlling neurotransmitter release in mammals using these compounds | ABBOTT LABORATORIES | 2003-12-02 | — | — | US | disclosed |
| EP-1257535-A1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 2002-11-20 | — | — | EP | disclosed |
| US-20020058646-A1 | Substituted pyridine compounds useful for controlling chemical synaptic transmission | ABBVIE INC. | 2002-05-16 | — | — | US | disclosed |
| US-20010034357-A1 | Substituted pyridine compounds useful for controlling chemical synaptic transmission | ABBOTT LABORATORIES | 2001-10-25 | — | — | US | disclosed |
| WO-2001056991-A1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058646-A1 | Substituted pyridine compounds useful for controlling chemical synaptic transmission | SLC18A2, SLC18A3, CHRNA4 | CHRNB2 19/4885CHRNA4 3/4885 |
| US-20010034357-A1 | Substituted pyridine compounds useful for controlling chemical synaptic transmission | SLC18A2, SLC18A3, CHRNA4 | CHRNB2 19/4885CHRNA4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.