⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15800558 | 0.67 | — | — | |
| SCHEMBL9212606 | 0.64 | — | — | |
| SCHEMBL9212445 | 0.62 | — | — | |
| SCHEMBL11035106 | 0.60 | — | — | |
| SCHEMBL9702349 | 0.60 | — | — | |
| SCHEMBL5888763 | 0.59 | — | — | |
| SCHEMBL26612937 | 0.59 | ALOX12 (0.39) | — | |
| SCHEMBL17104877 | 0.58 | — | — | |
| SCHEMBL1385588 | 0.58 | — | — | |
| SCHEMBL13716235 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039474-B2 | 2,3,4,9-tetrahydro-1H-carbazole derivatives as CRTH2 receptor antagonists | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-10-18 | — | — | US | claimed |
| EP-1833791-B1 | 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-03 | — | — | EP | claimed |
| US-20090270414-A1 | 2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2009-10-29 | — | — | US | claimed |
| US-RE47539-E1 | Aza-dibenzocyclooctynes and methods of making and using same | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2019-07-30 | — | — | US | disclosed |
| US-8912322-B2 | Aza-dibenzocyclooctynes and methods of making and using same | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-20120197012-A9 | AZA-DIBENZOCYCLOOCTYNES AND METHODS OF MAKING AND USING SAME | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2012-08-02 | — | — | US | disclosed |
| US-20120029186-A1 | AZA-DIBENZOCYCLOOCTYNES AND METHODS OF MAKING AND USING SAME | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2012-02-02 | — | — | US | disclosed |
| US-8039474-B2 | 2,3,4,9-tetrahydro-1H-carbazole derivatives as CRTH2 receptor antagonists | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-10-18 | — | — | US | disclosed |
| EP-1833791-B1 | 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-03 | — | — | EP | disclosed |
| US-20090270414-A1 | 2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2009-10-29 | — | — | US | disclosed |
| US-7417040-B2 | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-26 | — | — | US | disclosed |
| US-20050250753-A1 | Fused tricyclic compounds as inhibitors of 17beta-hydroxysteroid dehydrogenase 3 | BRISTOL-MYERS SQUIBB COMPANY | 2005-11-10 | — | — | US | disclosed |