Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CHRND | Q07001 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171810 | 0.93 | KDM5A (0.30) | — | |
| SCHEMBL5173279 | 0.78 | CHRNB2 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5173137 | 0.78 | CHRNB2 (0.42) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL5173782 | 0.76 | CHRNA7 (0.32) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL5174243 | 0.73 | CHRNA7 (0.33) | CHRNA7 | |
| SCHEMBL5172914 | 0.73 | KDM5A (0.30) | — | |
| Hydrochloric Acid SCHEMBL5174223 | 0.70 | CHRNB2 (0.40) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL5173067 | 0.69 | CHRNB2 (0.40) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL5172471 | 0.69 | — | — | |
| SCHEMBL5174771 | 0.69 | CHRM2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784184-A2 | THE USE OF N-ARYL DIAZASPIRACYCLIC COMPOUNDS IN THE TREATMENT OF ADDICTION | Targacept, Inc. (US) | 2007-05-16 | — | — | EP | claimed |
| WO-2006023630-A2 | THE USE OF N-ARYL DIAZASPIRACYCLIC COMPOUNDS IN THE TREATMENT OF ADDICTION | TARGACEPT, INC. (US) | 2006-03-02 | — | — | WO | claimed |