Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 6/20 | 0.40 |
| ▸ | MAOA | P21397 | 5/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5173002 | 0.88 | CASP1 (0.44) | MAOBMAOAHRH3 | |
| SCHEMBL4814288 | 0.76 | PBRM1 (0.47) | PBRM1IL4I1MAOBMAOAHRH3 | |
| SCHEMBL29289940 | 0.75 | CRBN (0.39) | BRD4MEN1KMT2A | |
| SCHEMBL1512782 | 0.75 | PBRM1 (0.53) | PBRM1IL4I1MAOBMAOAHRH3 | |
| SCHEMBL4811875 | 0.74 | PBRM1 (0.41) | PBRM1IL4I1MAOBMAOAHRH3 | |
| SCHEMBL23589273 | 0.73 | ALDH1A1 (0.48) | PBRM1IL4I1MAOBMAOABRD4 | |
| SCHEMBL8688671 | 0.72 | PBRM1 (0.50) | PBRM1IL4I1MAOBMAOAHRH3 | |
| SCHEMBL27538779 | 0.72 | DRD1 (0.41) | KMT2A | |
| SCHEMBL7605245 | 0.72 | PBRM1 (0.53) | PBRM1IL4I1MAOBMAOAHRH3 | |
| SCHEMBL4818350 | 0.72 | PBRM1 (0.58) | PBRM1IL4I1MAOBMAOAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-A1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | Abbott Laboratories (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005095387-A1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2005-10-13 | — | — | WO | disclosed |