Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171662 | 0.84 | SLC6A2 (0.36) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB3 | |
| SCHEMBL5174487 | 0.83 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNA3CHRNB4 | |
| SCHEMBL5172835 | 0.80 | CHRNA3 (0.40) | CHRNB2CHRNA4CHRNA3CHRNB4 | |
| SCHEMBL5175204 | 0.79 | CHRNB2 (0.33) | CHRNB2CHRNA4CHRNA3CHRNB4 | |
| SCHEMBL5174317 | 0.77 | CHRNB2 (0.38) | CHRNB2CHRNA4 | |
| SCHEMBL5173980 | 0.77 | SLC6A2 (0.37) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB3 | |
| SCHEMBL5175386 | 0.75 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB3 | |
| Hydrochloric Acid SCHEMBL5174223 | 0.74 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB3 | |
| SCHEMBL5173984 | 0.73 | CHRNA3 (0.42) | CHRNB2CHRNA4CHRNA3CHRNB4 | |
| SCHEMBL5173061 | 0.72 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNA3CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784184-A2 | THE USE OF N-ARYL DIAZASPIRACYCLIC COMPOUNDS IN THE TREATMENT OF ADDICTION | Targacept, Inc. (US) | 2007-05-16 | — | — | EP | claimed |
| WO-2006023630-A2 | THE USE OF N-ARYL DIAZASPIRACYCLIC COMPOUNDS IN THE TREATMENT OF ADDICTION | TARGACEPT, INC. (US) | 2006-03-02 | — | — | WO | claimed |