Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 19/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13300376 | 0.82 | ALDH1A1 (0.38) | TLR8TLR7 | |
| SCHEMBL17693700 | 0.79 | TLR8 (0.57) | TLR8TLR7 | |
| SCHEMBL8695685 | 0.79 | TLR8 (0.64) | TLR8TLR7L3MBTL1 | |
| SCHEMBL11752787 | 0.79 | TLR8 (0.73) | TLR8TLR7L3MBTL1 | |
| SCHEMBL17035544 | 0.78 | TLR8 (0.59) | TLR8TLR7L3MBTL1 | |
| SCHEMBL19495041 | 0.77 | TLR8 (0.71) | TLR8TLR7 | |
| SCHEMBL13300422 | 0.77 | ALDH1A1 (0.35) | TLR8 | |
| SCHEMBL20434302 | 0.76 | TLR8 (0.69) | TLR8TLR7L3MBTL1 | |
| SCHEMBL2848341 | 0.75 | TLR8 (0.52) | TLR8TLR7 | |
| SCHEMBL536664 | 0.74 | CHUK (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684236-B2 | Process of preparation of N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide | LONZA AG (CH) | 2007-12-26 | — | — | EP | disclosed |
| CN-1193991-C | Method for preparing 2,5-diamino-4,6-dichloropyrimidine | LONZE AG (CH) | 2005-03-23 | — | — | CN | disclosed |
| CN-1065862-C | N- (2-amino-4, 6-dichloropyrimidin-5-yl) formamide and preparation method thereof | LONZA AG (CH) | 2001-05-16 | — | — | CN | disclosed |
| CN-1259517-A | Method for preparing 2,5-diamino-4,6-dichloropyrimidine | LONZE AG (CH) | 2000-07-12 | — | — | CN | disclosed |
| EP-0684236-B1 | N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide and process for its production | LONZA AG (CH) | 1998-06-24 | — | — | EP | disclosed |
| US-5744601-A | N-(2-amino-4, 6-dichlopyrimidine-5-yl) formanide, and a process for its preparation | LONZA AG (CH) | 1998-04-28 | — | — | US | disclosed |
| US-5693800-A | N-(2-amino-4,6-dichloropyrimidine-5-yl) formamide and a process for its preparation | LONZA AG (CH) | 1997-12-02 | — | — | US | disclosed |
| US-5663340-A | N-(2-amino-4,6-dichloropyrimidine-5-yl)formamide, and a process for its preparation | LONZA AG (CH) | 1997-09-02 | — | — | US | disclosed |
| US-5583226-A | 4,6-dichloropyrimidine and related compounds | LONZA AG (CH) | 1996-12-10 | — | — | US | disclosed |
| EP-0684236-A2 | N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide and process for its production | LONZA AG (CH) | 1995-11-29 | — | — | EP | disclosed |