Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2183270 | 0.84 | CYP2C19 (0.60) | CYP2C19KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL4595012 | 0.78 | PTPN1 (0.45) | CYP2C19KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL21612890 | 0.75 | PTGDR2 (0.42) | CYP2C19KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL19438437 | 0.75 | CYP2C19 (0.46) | CYP2C19KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL29885821 | 0.74 | CYP3A4 (0.48) | CYP2C19ALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL1094342 | 0.74 | CYP3A4 (0.48) | CYP2C19ALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL11440531 | 0.73 | FFAR1 (0.46) | CYP2C19CYP1A2CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL2101990 | 0.73 | PTGDR2 (0.54) | CYP2C19KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL2103750 | 0.72 | PKM (0.65) | PTGDR2 | |
| SCHEMBL9797454 | 0.72 | CYP2C19 (0.44) | CYP2C19KDM4EUSP2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784388-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021759-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2006-03-02 | — | — | WO | disclosed |