Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | BRAF | P15056 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476621 | 0.90 | MAPK14 (0.42) | MAPK14BRAF | |
| SCHEMBL4463798 | 0.89 | BRAF (0.40) | BRAFLMNA | |
| SCHEMBL5176158 | 0.89 | MAPK14 (0.39) | MAPK14BRAFLMNA | |
| SCHEMBL5177850 | 0.88 | BRAF (0.38) | BRAFLMNAABL1 | |
| SCHEMBL13935932 | 0.86 | BRAF (0.51) | BRAF | |
| SCHEMBL1378709 | 0.86 | MAPK14 (0.39) | MAPK14BRAF | |
| Pivalamide SCHEMBL5176151 | 0.86 | MAPK14 (0.40) | MAPK14BRAF | |
| SCHEMBL5178018 | 0.84 | MAPK14 (0.41) | MAPK14BRAFABL1 | |
| SCHEMBL13935926 | 0.81 | LMNA (0.37) | MAPK14BRAFLMNAABL1 | |
| SCHEMBL5179141 | 0.81 | BRAF (0.47) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485657-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7485657-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| EP-1756065-A1 | ANTI-CYTOKINE HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115991-A1 | ANTI-CYTOKINE HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |