Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493708 | 0.77 | HTR6 (0.54) | KDM4EMAPTGAAPTK2BALDH1A1 | |
| SCHEMBL25894824 | 0.75 | MAPT (0.88) | KDM4EMAPTGAAPTK2BALDH1A1 | |
| SCHEMBL16965450 | 0.75 | JAK2 (0.56) | KDM4EMAPTGAAPTK2BALDH1A1 | |
| SCHEMBL12892361 | 0.75 | KDM4E (0.55) | KDM4EMAPTGAAPTK2BALDH1A1 | |
| SCHEMBL28051294 | 0.74 | RPS6KA3 (0.59) | KDM4EMAPTGAAPTK2BALDH1A1 | |
| SCHEMBL28577095 | 0.74 | MELK (0.65) | KDM4EMAPTGAAPTK2BALDH1A1 | |
| SCHEMBL14851170 | 0.74 | KDM4E (0.51) | KDM4EMAPTGAAPTK2BALDH1A1 | |
| SCHEMBL1493668 | 0.74 | HRH4 (0.52) | HRH4HRH3 | |
| SCHEMBL31173630 | 0.73 | MAPT (0.60) | KDM4EMAPTGAAPTK2BALDH1A1 | |
| SCHEMBL20475482 | 0.73 | MAPT (0.60) | KDM4EMAPTGAAPTK2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103121973-A | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG | 2013-05-29 | — | — | CN | disclosed |
| CN-103121972-A | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG | 2013-05-29 | — | — | CN | disclosed |
| EP-1761505-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | Novartis AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006000420-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-01-05 | — | — | WO | disclosed |