Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.63 |
| ▸ | BCR | P11274 | 6/20 | 0.63 |
| ▸ | LYN | P07948 | 4/20 | 0.63 |
| ▸ | KIT | P10721 | 10/20 | 0.62 |
| ▸ | CSF1R | P07333 | 8/20 | 0.62 |
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | BRAF | P15056 | 3/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | YES1 | P07947 | 1/20 | 0.62 |
| ▸ | HCK | P08631 | 1/20 | 0.62 |
| ▸ | FGR | P09769 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | SLC25A6 | P12236 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | NQO2 | P16083 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.62 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4830586 | 0.89 | KIT (0.77) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL717868 | 0.89 | KIT (0.69) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL716232 | 0.86 | ABL1 (0.75) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL5133079 | 0.84 | ABL1 (0.54) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL3561586 | 0.83 | KIT (0.71) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL717080 | 0.82 | ABL1 (0.80) | ABL1BCRLYNKITCSF1R | |
| Hydrochloric Acid SCHEMBL6014047 | 0.82 | KIT (0.70) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL14286281 | 0.82 | ABL1 (0.84) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL5133080 | 0.81 | ABL1 (0.50) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL5025223 | 0.81 | BRAF (0.73) | ABL1BCRLYNKITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742633-A2 | USE OF C-KIT INHIBITORS FOR TREATING FIBROSIS | AB Science (FR) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005115385-A1 | USE OF C-KIT INHIBITORS FOR TREATING ACNE | AB SCIENCE (FR) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005102346-A2 | USE OF C-KIT INHIBITORS FOR TREATING FIBROSIS | AB SCIENCE (FR) | 2005-11-03 | — | — | WO | disclosed |