Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 10/20 | 0.54 |
| ▸ | KIT | P10721 | 8/20 | 0.54 |
| ▸ | BCR | P11274 | 7/20 | 0.54 |
| ▸ | CSF1R | P07333 | 7/20 | 0.54 |
| ▸ | LYN | P07948 | 5/20 | 0.54 |
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | HCK | P08631 | 1/20 | 0.54 |
| ▸ | FGR | P09769 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | SLC25A6 | P12236 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133080 | 0.92 | ABL1 (0.50) | ABL1KITBCRCSF1RLYN | |
| SCHEMBL5176339 | 0.84 | ABL1 (0.63) | ABL1KITBCRCSF1RLYN | |
| SCHEMBL4830586 | 0.81 | KIT (0.77) | ABL1KITBCRCSF1RLYN | |
| SCHEMBL717868 | 0.80 | KIT (0.69) | ABL1KITBCRCSF1RLYN | |
| SCHEMBL717080 | 0.79 | ABL1 (0.80) | ABL1KITBCRCSF1RLYN | |
| SCHEMBL715741 | 0.78 | ABL1 (0.80) | ABL1KITBCRCSF1RLYN | |
| SCHEMBL3561586 | 0.78 | KIT (0.71) | ABL1KITBCRCSF1RLYN | |
| SCHEMBL716627 | 0.77 | ABL1 (0.80) | ABL1KITBCRCSF1RLYN | |
| Hydrochloric Acid SCHEMBL6014047 | 0.77 | KIT (0.70) | ABL1KITBCRCSF1RLYN | |
| SCHEMBL5025223 | 0.77 | BRAF (0.73) | ABL1KITBCRCSF1RLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255141-A1 | Modulators of signal transduction mediated by certain native and/or mutant tyrosine kinases; antiproliferative, anticarcinogenic, antiallergen, and antiinflammatory agents; metabolic and neurodegenerative disorders | AB SCIENCE | 2008-10-16 | — | — | US | claimed |
| US-20070032521-A1 | Use of c-kit inhibitors for treating type II diabetes | AB SCIENCE | 2007-02-08 | — | — | US | claimed |
| WO-2005056577-A2 | PEPTIDE INHIBITORS OF HIV | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032521-A1 | Use of c-kit inhibitors for treating type II diabetes | KIT, CPA3, CMA1 | ABL1 233/4885KIT 1/4885BCR 3609/4885 |
| US-20080255141-A1 | Modulators of signal transduction mediated by certain native and/or mutant tyrosine kinases; antiproliferative, anticarcinogenic, antiallergen, and antiinflammatory agents; metabolic and neurodegenerative disorders | KIT, MAP3K1, MAP3K6 | ABL1 176/4885KIT 1/4885BCR 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.