Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 9/20 | 0.42 |
| ▸ | RAF1 | P04049 | 5/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098029 | 0.80 | TRPA1 (0.46) | TRPA1BRAFRAF1PDGFRARET | |
| SCHEMBL5179191 | 0.79 | TRPA1 (0.54) | TRPA1BRAFRAF1KDM1ARET | |
| SCHEMBL4245503 | 0.79 | KDM1A (0.65) | TRPA1BRAFRAF1KDM1AEGFR | |
| SCHEMBL1098795 | 0.78 | ENPP1 (0.58) | EPHA2KDM1AKDRERBB2EPHB4 | |
| SCHEMBL1099027 | 0.78 | PDGFRA (0.50) | BRAFRAF1PDGFRAKDRCSF1R | |
| SCHEMBL4517992 | 0.75 | FLT4 (0.54) | BRAFRAF1PDGFRAKDRCSF1R | |
| SCHEMBL29354598 | 0.74 | EPHA2 (0.47) | EPHA2PDGFRAKDRERBB2KIT | |
| SCHEMBL22441582 | 0.74 | EPHA2 (0.47) | EPHA2PDGFRAKDRERBB2KIT | |
| SCHEMBL4524921 | 0.73 | FLT4 (0.52) | BRAFRAF1PDGFRAKDRCSF1R | |
| SCHEMBL4523620 | 0.73 | FLT4 (0.54) | BRAFRAF1PDGFRAKDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802591-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040520-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |