Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966306 | 0.86 | MAPT (0.51) | MAPTCA1CA2TDP1CA12 | |
| SCHEMBL1791209 | 0.84 | L3MBTL1 (0.52) | MAPTCA1CA2TDP1CA12 | |
| SCHEMBL14966780 | 0.84 | CA1 (0.52) | MAPTCA1CA2TDP1CA12 | |
| SCHEMBL3659071 | 0.84 | MAPK1 (0.49) | MAPTCA1CA2KMT2ATSHR | |
| SCHEMBL16684851 | 0.84 | L3MBTL1 (0.52) | MAPTCA1CA2TDP1CA12 | |
| SCHEMBL8735702 | 0.82 | LOXL2 (0.58) | MAPTCA1CA2TDP1CA12 | |
| SCHEMBL19940311 | 0.82 | MAPT (0.50) | MAPTCA1CA2TDP1CA12 | |
| SCHEMBL27542641 | 0.82 | MAPT (0.50) | MAPTCA1CA2TDP1CA12 | |
| SCHEMBL14967316 | 0.81 | MAPT (0.63) | MAPTTDP1RAB9AMEN1KMT2A | |
| SCHEMBL4210049 | 0.81 | FFAR1 (0.53) | MAPTCA1CA2TDP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776338-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006013048-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |