Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 12/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL373960 | 0.79 | EGFR (0.57) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL12485614 | 0.76 | MEN1 (0.87) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL5563364 | 0.76 | CYP1A2 (0.50) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL4724653 | 0.73 | NPC1 (0.55) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL374182 | 0.73 | EGFR (0.49) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL374411 | 0.72 | LCK (0.49) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL374265 | 0.71 | TNNI3K (0.56) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL28806262 | 0.71 | MEN1 (0.46) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL374148 | 0.71 | EGFR (0.71) | TNNI3KMEN1KMT2AEGFRNPC1 | |
| SCHEMBL147860 | 0.70 | MKNK1 (0.44) | CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | Novartis AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006000420-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-01-05 | — | — | WO | disclosed |