Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 12/20 | 0.46 |
| ▸ | EGFR | P00533 | 8/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28806263 | 0.81 | MEN1 (0.45) | MEN1KMT2ATNNI3KEGFRNPC1 | |
| SCHEMBL4724653 | 0.79 | NPC1 (0.55) | MEN1KMT2ATNNI3KEGFRERBB3 | |
| SCHEMBL374182 | 0.79 | EGFR (0.49) | MEN1KMT2ATNNI3KEGFRERBB3 | |
| SCHEMBL27536722 | 0.75 | ALDH1A1 (0.42) | MEN1KMT2ARAB9A | |
| SCHEMBL373960 | 0.74 | EGFR (0.57) | MEN1KMT2ATNNI3KEGFRERBB3 | |
| SCHEMBL22592520 | 0.73 | L3MBTL1 (0.66) | MEN1KMT2ATNNI3KEGFRERBB3 | |
| SCHEMBL12485614 | 0.72 | MEN1 (0.87) | MEN1KMT2ATNNI3KEGFRERBB3 | |
| SCHEMBL5177808 | 0.71 | TNNI3K (0.52) | MEN1KMT2ATNNI3KEGFRNPC1 | |
| SCHEMBL22531924 | 0.70 | CD274 (0.53) | EGFRERBB3 | |
| SCHEMBL2270981 | 0.69 | NPC1 (0.65) | MEN1KMT2ATNNI3KEGFRERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103121972-A | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG | 2013-05-29 | — | — | CN | disclosed |
| CN-103121973-A | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG | 2013-05-29 | — | — | CN | disclosed |