Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 5/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2208858 | 0.88 | HRH3 (0.44) | ACP1HRH3SCN9AMAP2K1CHEK2 | |
| SCHEMBL1381216 | 0.83 | HRH3 (0.61) | ACP1HRH3SCN9A | |
| SCHEMBL1377869 | 0.83 | HRH3 (0.61) | HRH3SCN9A | |
| SCHEMBL5178917 | 0.83 | HRH3 (0.51) | HRH3SCN9A | |
| SCHEMBL1380830 | 0.82 | HRH3 (0.67) | HRH3SCN9A | |
| SCHEMBL1380750 | 0.81 | HRH3 (0.50) | HRH3SCN9A | |
| SCHEMBL1381575 | 0.81 | HRH3 (0.56) | HRH3SCN9A | |
| SCHEMBL1381719 | 0.81 | HRH3 (0.51) | HRH3SCN9A | |
| SCHEMBL1380359 | 0.80 | HRH3 (0.53) | ACP1HRH3SCN9AP2RY12PDE3B | |
| SCHEMBL1378414 | 0.80 | SCN9A (0.53) | HRH3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805166-A1 | QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006045416-A1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-04 | — | — | WO | disclosed |