Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 8/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163343 | 0.85 | PTPN1 (0.67) | PTPN1 | |
| SCHEMBL5164813 | 0.74 | PTPN1 (0.53) | PTPN1PTPN2ACLY | |
| SCHEMBL5163348 | 0.72 | PTPN1 (0.47) | PTPN1MCL1ACMSDDHFRHNF4A | |
| SCHEMBL5164817 | 0.67 | PTPN1 (0.42) | PTPN1MCL1ACLY | |
| SCHEMBL5166571 | 0.67 | PTPN1 (0.47) | PTPN1PTPN2 | |
| SCHEMBL5164528 | 0.65 | PTPN1 (0.45) | PTPN1PTPN2 | |
| SCHEMBL21872020 | 0.63 | PTPN1 (0.53) | PTPN1ACLY | |
| SCHEMBL330660 | 0.63 | ACMSD (0.66) | MCL1ACMSDDHFRHNF4AACLY | |
| SCHEMBL9678205 | 0.62 | KDM4E (0.43) | PTPN1MCL1ACMSDDHFRHNF4A | |
| SCHEMBL11696480 | 0.61 | MCL1 (0.55) | MCL1ACMSDDHFRHNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |