Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 4/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935348 | 1.00 | BCL2A1 (0.45) | BCL2A1SLC6A2SLC6A4SLC6A3ABL1 | |
| SCHEMBL4938713 | 1.00 | BCL2A1 (0.45) | BCL2A1SLC6A2SLC6A4SLC6A3ABL1 | |
| SCHEMBL14311559 | 0.88 | ADAMTS5 (0.40) | BCL2A1SLC6A2SLC6A4WEE1ADAMTS5 | |
| SCHEMBL3465481 | 0.84 | ADAMTS5 (0.42) | WEE1ADAMTS5ADAMTS4 | |
| SCHEMBL3465038 | 0.84 | ADAMTS5 (0.42) | WEE1ADAMTS5ADAMTS4 | |
| SCHEMBL3465040 | 0.84 | ADAMTS5 (0.42) | WEE1ADAMTS5ADAMTS4 | |
| SCHEMBL3465474 | 0.84 | ADAMTS5 (0.42) | WEE1ADAMTS5ADAMTS4 | |
| SCHEMBL3465043 | 0.84 | ADAMTS5 (0.42) | WEE1ADAMTS5ADAMTS4 | |
| SCHEMBL23134696 | 0.83 | AR (0.52) | — | |
| SCHEMBL4596985 | 0.83 | AR (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761512-A1 | NOVEL ALKYL SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005123707-A1 | NOVEL ALKYL SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2005-12-29 | — | — | WO | disclosed |