Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.49 |
| ▸ | RHOC | P08134 | 4/20 | 0.44 |
| ▸ | RHOA | P61586 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14880119 | 0.81 | HDAC6 (0.72) | CES2GAAHDAC3HDAC8HDAC6 | |
| SCHEMBL2743436 | 0.81 | CES2 (0.61) | CES2 | |
| SCHEMBL3277286 | 0.79 | GAA (0.61) | CES2GAAHDAC3HDAC8HDAC6 | |
| SCHEMBL1004777 | 0.79 | CES2 (0.59) | CES2GAAHDAC3HDAC8HDAC6 | |
| SCHEMBL2191271 | 0.78 | CES2 (0.70) | CES2GAAHDAC3HDAC8HDAC6 | |
| SCHEMBL8767967 | 0.77 | GAA (0.58) | CES2GAAHDAC3HDAC8HDAC6 | |
| SCHEMBL20877084 | 0.76 | CES2 (0.55) | CES2GAAHDAC3HDAC8HDAC6 | |
| SCHEMBL15788816 | 0.76 | GAA (0.62) | CES2GAAHDAC3HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL8503520 | 0.76 | GAA (0.57) | CES2GAAHDAC3HDAC8HDAC6 | |
| SCHEMBL16180051 | 0.75 | CES2 (0.73) | CES2GAAHDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802579-A1 | 3-ARYLAMINO PYRIDINE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2007-07-04 | — | — | EP | claimed |
| WO-2006045514-A1 | 3-ARYLAMINO PYRIDINE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2006-05-04 | — | — | WO | claimed |