Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL517902 | 0.90 | ALDH1A1 (0.37) | ALDH1A1LMNASIRT6MAPTMEN1 | |
| SCHEMBL517903 | 0.78 | ALDH1A1 (0.37) | ALDH1A1LMNASIRT6MAPTMEN1 | |
| SCHEMBL517496 | 0.70 | ALDH1A1 (0.41) | ALDH1A1LMNASIRT6MAPTMEN1 | |
| SCHEMBL10182159 | 0.67 | DRD2 (0.41) | ALDH1A1LMNASIRT6MAPTMEN1 | |
| SCHEMBL30184525 | 0.66 | ALDH1A1 (0.52) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL30184632 | 0.65 | ALDH1A1 (0.44) | ALDH1A1LMNASIRT6MAPTTDP1 | |
| SCHEMBL11916217 | 0.65 | ALDH1A1 (0.51) | ALDH1A1LMNASIRT6MAPTMEN1 | |
| SCHEMBL22233801 | 0.65 | ALDH1A1 (0.48) | ALDH1A1LMNASIRT6MAPTMEN1 | |
| SCHEMBL16989744 | 0.65 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTL3MBTL1PKM | |
| SCHEMBL16989746 | 0.65 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTL3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461170-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2013-06-11 | — | — | US | disclosed |
| US-20120028924-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028924-A1 | CHEMICAL COMPOUNDS | ALK, BRAF, ABL1 | ALDH1A1 214/4885LMNA 1889/4885SIRT6 4345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.