Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PMP22 | Q01453 | 1/20 | 0.72 |
| ▸ | ADRB2 | P07550 | 10/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stearic Acid SCHEMBL518159 | 0.90 | PMP22 (0.73) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Stearic Acid SCHEMBL5145217 | 0.86 | ADRB2 (0.70) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL7775807 | 0.86 | ADRB2 (0.70) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL7778379 | 0.86 | ADRB2 (0.70) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL2405201 | 0.85 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL2556890 | 0.85 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Levosalbutamol SCHEMBL33281 | 0.85 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL33279 | 0.85 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL33280 | 0.85 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL15995296 | 0.84 | PMP22 (0.97) | PMP22ADRB2ADRB1HIF1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1920763-B2 | Pharmaceutical compositions for inhalation | VECTURA LTD (GB) | 2022-06-15 | — | — | EP | disclosed |
| US-10449161-B2 | Pharmaceutical compositions for inhalation | VECTURA LIMITED (GB) | 2019-10-22 | — | — | US | disclosed |
| US-10238601-B2 | Particles for use in a pharmaceutical composition | VECTURA LIMITED (GB) | 2019-03-26 | — | — | US | disclosed |
| US-10188612-B2 | Pharmaceutical compositions for inhalation | VECTURA LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| EP-2298279-B1 | Pharmaceutical compositions for inhalation | VECTURA LTD (GB) | 2018-11-14 | — | — | EP | disclosed |
| EP-2168571-B1 | Particles for use in a Pharmaceutical Composition | VECTURA LTD (GB) | 2018-08-22 | — | — | EP | disclosed |
| US-20170216202-A1 | PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | VECTURA LTD (GB) | 2017-08-03 | — | — | US | disclosed |
| US-20170172947-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHALATION | VECTURA LTD (GB) | 2017-06-22 | — | — | US | disclosed |
| US-9585839-B2 | Particles for use in a pharmaceutical composition | VECTURA LIMITED (GB) | 2017-03-07 | — | — | US | disclosed |
| EP-1337239-B2 | PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | VECTURA LTD (GB) | 2015-11-25 | — | — | EP | disclosed |
| EP-2168571-A2 | Particles for use in a Pharmaceutical Composition | Vectura Limited (GB) | 2010-03-31 | — | — | EP | disclosed |
| EP-1337239-B1 | PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | VECTURA LTD (GB) | 2009-10-21 | — | — | EP | disclosed |
| EP-1920763-A1 | Pharmaceutical compositions for inhalation | Vectura Limited (GB) | 2008-05-14 | — | — | EP | disclosed |
| EP-1337241-B1 | METHOD OF PREPARING MICROPARTICLES FOR USE IN PHARMACEUTICAL COMPOSITIONS FOR INHALATION | VECTURA LTD (GB) | 2008-01-02 | — | — | EP | disclosed |
| US-20040071635-A1 | Particles for use in a pharmaceutical composition | VECTURA GROUP PLC (GB) | 2004-04-15 | — | — | US | disclosed |
| US-20040047810-A1 | Microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the | VECTURA GROUP PLC (GB) | 2004-03-11 | — | — | US | disclosed |
| EP-1337239-A2 | PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | Vectura Limited (GB) | 2003-08-27 | — | — | EP | disclosed |
| EP-1337241-A2 | PHARMACEUTICAL COMPOSITIONS FOR INHALATION | Vectura Limited (GB) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002043700-A2 | PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | VECTURA LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |
| WO-2002043702-A2 | PHARMACEUTICAL COMPOSITIONS FOR INHALATION | VECTURA LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |