Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.55 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.55 |
| ▸ | PPARG | P37231 | 7/20 | 0.55 |
| ▸ | PPARD | Q03181 | 7/20 | 0.55 |
| ▸ | PPARA | Q07869 | 7/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TLR2 | O60603 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | FABP4 | P15090 | 2/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.55 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetradecanamide SCHEMBL5182998 | 0.92 | FAAH (0.47) | PLA2G2APLA2G4AGPR84PPARGPPARD | |
| Palmitamide SCHEMBL5180724 | 0.92 | FAAH (0.47) | PLA2G2APLA2G4AGPR84PPARGPPARD | |
| Acetic Acid SCHEMBL6696904 | 0.92 | FAAH (0.47) | PLA2G2APLA2G4AGPR84PPARGPPARD | |
| Acetic Acid SCHEMBL2905199 | 0.88 | EPHX1 (0.55) | PLA2G2AMEN1KMT2A | |
| Acetic Acid SCHEMBL3289314 | 0.88 | EPHX1 (0.55) | PLA2G2AMEN1KMT2A | |
| Dodine SCHEMBL22124 | 0.88 | EPHX1 (0.55) | PLA2G2AMEN1KMT2A | |
| Dodine SCHEMBL9055972 | 0.88 | EPHX1 (0.55) | PLA2G2AMEN1KMT2A | |
| Dodine SCHEMBL9766434 | 0.88 | EPHX1 (0.55) | PLA2G2AMEN1KMT2A | |
| Acetic Acid SCHEMBL2905260 | 0.88 | EPHX1 (0.55) | PLA2G2AMEN1KMT2A | |
| Acetic Acid SCHEMBL29256286 | 0.88 | EPHX1 (0.55) | PLA2G2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282520-B2 | External preparation | LION CORPORATION (JP) | 2007-10-16 | — | — | US | disclosed |
| EP-1437119-B1 | EXTERNAL PREPARATION CONTAIINING GALLIC ACID DERIVATIVES | LION CORP (JP) | 2007-08-15 | — | — | EP | disclosed |
| EP-1437119-A1 | EXTERNAL PREPARATION | Lion Corporation (JP) | 2004-07-14 | — | — | EP | disclosed |