Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RRM1 | P23921 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7066326 | 1.00 | EPHX1 (0.44) | EPHX1DPP7CA1CA2SMN1; SMN2 | |
| SCHEMBL24709285 | 0.98 | EPHX1 (0.47) | EPHX1DPP7RRM1CASP2MEN1 | |
| SCHEMBL29019997 | 0.98 | EPHX1 (0.47) | EPHX1DPP7RRM1CASP2MEN1 | |
| Hydrochloric Acid SCHEMBL7769070 | 0.96 | EPHX1 (0.46) | EPHX1DPP7RRM1CASP2MEN1 | |
| SCHEMBL11508997 | 0.94 | ALOX15 (0.43) | EPHX1DPP7CA1CA2MEN1 | |
| SCHEMBL12827797 | 0.94 | ALOX15 (0.43) | EPHX1DPP7CA1CA2MEN1 | |
| SCHEMBL3207666 | 0.85 | — | — | |
| SCHEMBL6997820 | 0.85 | — | — | |
| SCHEMBL31321062 | 0.85 | — | — | |
| Iodide SCHEMBL6053667 | 0.83 | SCN1A (0.41) | EPHX1CA1CA2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556054-A4 | ANTAGONIZING NK1 RECEPTORS INHIBITS CONSUMPTION OF SUBSTANCES OF ABUSE | UNIV CALIFORNIA (US) | 2007-09-05 | — | — | EP | disclosed |
| US-20060205724-A1 | Antagonizing nk-1 receptors inhibits consumption of substances of abuse | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2006-09-14 | — | — | US | disclosed |
| EP-1556054-A1 | ANTAGONIZING NK1 RECEPTORS INHIBITS CONSUMPTION OF SUBSTANCES OF ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003101459-A1 | ANTAGONIZING NK1 RECEPTORS INHIBITS CONSUMPTION OF SUBSTANCES OF ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-12-11 | — | — | WO | disclosed |
| US-20020002198-A1 | Chemical synergy to elevate growth hormone release in vertebrates | PARR TYLER B (US) | 2002-01-03 | — | — | US | disclosed |
| US-5773441-A | PRODRUGS; ANIMAL HUSBANDRY | ELI LILLY AND COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0761220-A1 | 2-Acylaminopropanamides as growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 1997-03-12 | — | — | EP | disclosed |
| US-5565568-A | USEFUL IN TREATMENT OR PREVENTION OF A PHYSIOLOGICAL DISORDER ASSOCIATED WITH AN EXCESS OF TACHYKININS | ELI LILLY AND COMPANY (US) | 1996-10-15 | — | — | US | disclosed |