Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | RHOC | P08134 | 1/20 | 0.37 |
| ▸ | RHOA | P61586 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435775 | 0.92 | L3MBTL1 (0.41) | KLKB1MAPTPTGDR2HRH3RHOC | |
| SCHEMBL5430825 | 0.89 | MTNR1A (0.42) | KLKB1MAPTPTGDR2ALDH1A1 | |
| SCHEMBL14902860 | 0.86 | KLKB1 (0.40) | KLKB1MAPTPTGDR2HRH3ALDH1A1 | |
| SCHEMBL5433959 | 0.86 | KLKB1 (0.42) | KLKB1MAPTPTGDR2HRH3ALDH1A1 | |
| SCHEMBL5183183 | 0.84 | MAPT (0.44) | MAPTPTGDR2HRH3ALDH1A1GAA | |
| SCHEMBL5183960 | 0.83 | CA12 (0.43) | KLKB1MAPT | |
| SCHEMBL5439520 | 0.83 | MAPT (0.46) | MAPTPTGDR2HRH3KMT2A | |
| SCHEMBL5184250 | 0.83 | PTGDR2 (0.40) | KLKB1MAPTPTGDR2HRH3ALDH1A1 | |
| SCHEMBL5184239 | 0.83 | MAPT (0.39) | KLKB1MAPTPTGDR2HRH3KMT2A | |
| SCHEMBL5442869 | 0.82 | SMN1; SMN2 (0.43) | MAPTPTGDR2KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799646-A1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006030032-A1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-23 | — | — | WO | disclosed |