Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184088 | 0.92 | TRPV1 (0.45) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL5185052 | 0.88 | KDM4E (0.48) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL5184813 | 0.87 | NPSR1 (0.49) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL5231291 | 0.82 | PABPC1 (0.58) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL4950035 | 0.82 | KDR (0.43) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL4950199 | 0.82 | KDR (0.39) | POLBMAPTRAB9AALDH1A1TSHR | |
| SCHEMBL4950537 | 0.80 | PDE4B (0.43) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL4952020 | 0.79 | CNR1 (0.41) | SYKHDAC4 | |
| SCHEMBL5185017 | 0.78 | RAB9A (0.46) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL5185045 | 0.78 | NPC1 (0.49) | NPC1POLBMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758920-A1 | BACTERIAL EFFLUX PUMP INHIBITORS AND METHODS OF TREATING BACTERIAL INFECTIONS | MPEX PHARMACEUTICALS, INC. (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005113579-A1 | BACTERIAL EFFLUX PUMP INHIBITORS AND METHODS OF TREATING BACTERIAL INFECTIONS | MPEX PHARMACEUTICALS, INC. (US) | 2005-12-01 | — | — | WO | disclosed |