Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28948755 | 0.84 | DYRK1A (0.58) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL8756541 | 0.81 | HASPIN (0.54) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL23148493 | 0.80 | GRIK2 (0.56) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL27772057 | 0.80 | SMPD1 (0.52) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8867584 | 0.79 | KDM4E (0.53) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL2333735 | 0.78 | SMPD1 (0.54) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL28273388 | 0.78 | PSEN1 (0.58) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL5185105 | 0.77 | TSPO (0.49) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1180482 | 0.76 | MEN1 (0.71) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL5186287 | 0.76 | PSEN1 (0.45) | KDM4EMEN1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293558-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | claimed |
| EP-1802299-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2007-07-04 | — | — | EP | claimed |
| WO-2006044425-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | claimed |
| US-20070293558-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
| US-20070293558-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
| US-20070293558-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
| EP-1802299-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044425-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293558-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | KCNH2, KCNJ11, KCNN1 | KDM4E 1362/4885MEN1 917/4885ALDH1A1 938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.